
To begin with this devastating combo, you'll need to have both
Sunny Smiles, Iconic Friend (up to 3 is possible!) as well as
Minuette, Clocked Up (again up to 3), out in play, preferably at your opponent's problem, and preferably with Bonus Points of 3.
Then play (face-down) a troublemaker,
Nightmare Moon.
The following round,
Nightmare Moon is revealed (turned face-up) and then the devastation begins!
First, all players discard their hands and draw 3 cards.
(In a multiplayer game this effect is even more devastating), but
Sunny Smiles, Iconic Friend powers up
+1 per card an opponent discards.
It's difficult to guess at how many cards your opponent(s) will have in their hand because the set up (getting 1-3 Sunny Smiles and 1-3
Minutettes out into play won't be early on in the game, not to mention what may happen in a multiplayer game). But for the sake of keeping things simple let's assume your opponent discards 4 cards. (But let's not forget or write off the possibility of your opponent having their maximum of 8 cards in their hand = +8! It is entirely possible for
Sunny Smiles to power up to 11-power!)
Sunny Smiles, Iconic Friend powers up to +4 (giving her a total power for the remainder of the turn of 7). If this isn't enough to defeat the Problem, you can trigger
another troublemaker phase by retiring a
Minuette, Clocked Up, forcing your opponent to discard another card, powering up
Sunny Smiles another +1.
You are still in your Troublemaker Phase. Immediately confront
Nightmare Moon, defeat her and gain +3 points.
Then play through the Main Phase (building up Friends if needed - don't forget
Sunny Smiles is still at 8 power!).
Then confront your opponent's problem, score 1 point (if you're the first, score it's bonus points (if planned right another 3), and then possibly, a Problem Faceoff - don't forget,
Sunny Smiles is
still at 8-power - (hopefully) win Problem Faceoff, score another 3 points.
If timed right and played right, this combo could score - if 1 turn - from
4 to 10 points! (That's approximately 25% - 67% of the game).
...
ouch!...
Now, the downside of this strategy is you would need, probably 3
Nightmare Moons in your deck to make this functional.... and even 1
Nightmare Moon can be difficult to find (being Ultra-rare) or extremely expensive. :(